Computational modelling of cardiac control following myocardial infarction using an in silico patient cohort.

ABSTRACT: Loss of cardiac physiological function following myocardial infarction (MI) is accompanied by neural adaptations in the baroreflex that are compensatory in the short term, but then become associated with long-term disease progression. One marker of these adaptations is decreased baroreflex sensitivity, a strong predictor of post-MI mortality. The relative contributions of cardiac remodelling and neural adaptation in the sensory, central brainstem and peripheral ganglionic loci to baroreflex sensitivity changes remain underexplored. We used a computational model-based approach that accounts for the short-term dynamics of closed-loop human cardiac control to integrate disparate experimental studies on neural adaptation following MI into a unified quantitative framework. We developed an ensem

SUBMITTER: Gee MM 

PROVIDER: S-EPMC11955869 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature