Stepwise dual antiplatelet therapy de-escalation in patients after drug coated balloon angioplasty (REC-CAGEFREE II): multicentre, randomised, open label, assessor blind, non-inferiority trial.

ABSTRACT:

Objectives

To investigate whether a less intense antiplatelet regimen could be used for people receiving drug coated balloons.

Design

Multicentre, randomised, open label, assessor blind, non-inferiority trial (REC-CAGEFREE II).

Setting

41 hospitals in China between 27 November 2021 and 21 January 2023.

Participants

1948 adults (18-80 years) with acute coronary syndrome who received treatment exclusively with paclitaxel-coated balloons according to the international drug coated balloon consensus.

Interventions

Participants were randomly assigned (1:1) to either the stepwise dual antiplatelet therapy (DAPT) de-escalation group (n=975) consisting of aspirin plus ticagrelor for one month, followed by five months of ticagrelor monotherapy, and then six months

SUBMITTER: Gao C 

PROVIDER: S-EPMC11955879 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature