N-Alkylation through the Borrowing Hydrogen Pathway Catalyzed by the Metal-Organic Framework-Supported Iridium-Monophosphine Complex.

ABSTRACT: Further development in the area of medicinal chemistry requires facile and atom-economical C-N bond formation from readily accessible precursors using recyclable and reusable catalysts with low process toxicity. In this work, direct N-alkylation of amines with alcohols is performed with a series of Ir-phosphine-functionalized metal-organic framework (MOF) heterogeneous catalysts. The grafted monophosphine-Ir complexes were studied comprehensively to illustrate the ligand-dependent reactivity. The afforded MOF catalysts exhibited high reactivity and selectivity toward N-alkylamine product formation, especially UiO-66-PPh₂-Ir, which showed 90% conversion after recycling with no catalyst residue remaining in the product after the reaction. Furthermore, analyses of the active

SUBMITTER: Chen W 

PROVIDER: S-EPMC11955943 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature