Renal impairment is prevalent in pediatric NAFLD/MASLD and associated with disease severity.

ABSTRACT:

Objectives

Renal impairment is prevalent in adults with nonalcoholic fatty liver disease (NAFLD/metabolic dysfunction associated steatotic liver disease [MASLD]) and is associated with increased mortality. Pediatric data are limited. Our objective was to determine the prevalence of hyperfiltration or chronic kidney disease (CKD) in children with NAFLD/MASLD and determine links with liver disease severity.

Methods

Data from children who had previously participated in prospective, multicenter, pediatric studies by the Nonalcoholic Steatohepatitis Clinical Research Network (NASH-CRN) were collected. Renal function was determined using the calculated glomerular filtration rate (cGFR). Hyperfiltration was defined as cGFR > 135 mL/min/1.73m², while CKD stage 2 or higher

SUBMITTER: Mouzaki M 

PROVIDER: S-EPMC11956019 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature