Single‑cell RNA‑Seq reveals PBMC profile alterations in a patient following a radiation accident.

ABSTRACT: Nuclear technology has been extensively used in various fields, increasing the possibility of radiation exposure to humans. Radiation exposure outcomes may be classified as whole-body irradiation or local irradiation. Clinically, local irradiation refers to the exposure of a relatively limited portion of the body, with injury confined to the directly exposed tissues. However, locally irradiated tissues can trigger systemic reactions through the release of inflammatory factors or damage to blood cells at the irradiated site. The circulating population of peripheral blood mononuclear cells (PBMCs), a component of normal tissue, is particularly sensitive to ionizing radiation. The present study applied single-cell RNA sequencing (scRNA-Seq) to profile PBMCs from one irradiated patient and 10

SUBMITTER: Yan T 

PROVIDER: S-EPMC11956132 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature