MiR-34-5p mediates 20E-induced autophagy in the fat body of Bombyx mori by targeting Atg1.

ABSTRACT:

Background

20-Hydroxyecdysone (20E) is an important hormone that regulates insect development and metamorphosis. The fat body of insects plays a crucial role in nutrient storage and energy metabolism and is considered the exchange center for regulating insect development. The fat body undergoes remarkable transformation during insect metamorphosis and is primarily regulated by 20E. microRNAs (miRNAs) have been identified in different insects and have multiple functions in various physiological processes. However, the interaction of 20E and miRNAs in fat body regulation remains unclear.

Results

We constructed six small RNA libraries using Bombyx mori fat body treated with 20E. Expression and functional analyses were conducted to identify 20E-responsive miRNAs. In total, 431 m

SUBMITTER: Qiao H 

PROVIDER: S-EPMC11956236 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature