Comprehensive molecular characteristics of hepatocellular carcinoma based on multi-omics analysis.

ABSTRACT:

Background

The high heterogeneity of hepatocellular carcinoma (HCC) poses challenges for precision treatment strategies. This study aims to use multi-omics methodologies to better understand its pathogenesis and discover biomarkers.

Methods

Quantitative proteomics was used to investigate hepatocellular carcinoma tissues (HCT) and their corresponding adjacent non-tumor tissues (DNT), obtained from six HCC patients. Untargeted metabolomics was applied to analyze the metabolic profiles of HCT and DNT of ten HCC patients. Statistical analyses, such as the Student's t-test, were performed to identify differentially expressed proteins (DEPs) and metabolites (DEMs) between the two groups. The functions and metabolic pathways involving DEPs and DEMs were annotated and enriched using

SUBMITTER: Wang YY 

PROVIDER: S-EPMC11956240 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature