Crosswalk between HRSD and MADRS outcomes for rTMS in patients with depression.

ABSTRACT:

Background

The Hamilton Rating Scale for Depression (HRSD) and the Montgomery-Åsberg Depression Rating Scale (MADRS) are the two most common clinician-rated scales to quantify depression symptom change in repetitive transcranial magnetic stimulation (rTMS) trials. However, it is unclear how the values of one scale translate to the other. Being able to translate scores between these scales could allow for aggregating rTMS clinical trial data.

Methods

Clinical data from two randomised rTMS clinical trials (FOURD and CARTBIND, total N=380) were pooled. We used five crosswalk models: (1) a pharmacotherapy equipercentile model, (2) an rTMS equipercentile model, (3) a linear regression model, (4) a random forest (RF) regression model and (5) a support vector regression (SVR) model

SUBMITTER: Chen X 

PROVIDER: S-EPMC11956309 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature