Mass distribution of azithromycin and child mortality among underweight infants in rural Niger: a subgroup analysis of the AVENIR cluster-randomised trial.

ABSTRACT:

Objective

Azithromycin has been shown to reduce all-cause child mortality. This subgroup analysis investigates azithromycin's mortality impact by underweight status using Azithromycine pour la Vie des Enfants au Niger: Implementation et Recherche (AVENIR) trial data.

Design

The AVENIR trial randomised communities into three arms: azithromycin for children aged 1-59 months, azithromycin for infants aged 1-11 months or placebo. Weight-for-age z-score was used to categorise children into subgroups of either moderate to severe underweight or not and severe underweight or not.

Setting

2880 communities with a population of less than 2500 people in the Dosso and Tahoua regions of Niger that participated in the AVENIR trial were included.

Participants

97 572 chi

SUBMITTER: Peterson B 

PROVIDER: S-EPMC11956350 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature