Bone marrow niches orchestrate stem-cell hierarchy and immune tolerance.

ABSTRACT: Stem cells reside in specialized microenvironments, termed niches, at several different locations in tissues^1-3. The differential functions of heterogeneous stem cells and niches are important given the increasing clinical applications of stem-cell transplantation and immunotherapy. Whether hierarchical structures among stem cells at distinct niches exist and further control aspects of immune tolerance is unknown. Here we describe previously unknown new hierarchical arrangements in haematopoietic stem cells (HSCs) and bone marrow niches that dictate both regenerative potential and immune privilege. High-level nitric oxide-generating (NO^hi) HSCs are refractory to immune attack and exhibit delayed albeit robust long-term reconstitution. Such highly immune-privileged, pr

SUBMITTER: Furuhashi K 

PROVIDER: S-EPMC11956426 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature