Serum phospholipids and sphingolipids are linked to early-stage osteoarthritis by lipidomic profiling.

ABSTRACT:

Background

Osteoarthritis (OA) is associated with abnormal lipid metabolism, wherein elevated levels of phospholipids (PLs) and sphingolipids (SLs) in human and canine synovial fluid (SF) have been observed. The aim of this lipidomic study was to evaluate how closely blood lipid levels reflect changes in SF, building on previous findings.

Methods

Lipids were extracted from knee SF and serum of 44 joint-healthy donors and 58 early (eOA) or late OA (lOA) patients. By electrospray ionization tandem mass spectrometry (ESI-MS/MS), we quantified the extracted lipids and conducted comprehensive statistical analyses.

Results

Human SF and serum had similar PL and SL compositions. Quantifying 91 lipid species from 6 major classes revealed OA-related changes in serum, with the l

SUBMITTER: Eichner G 

PROVIDER: S-EPMC11956431 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature