Metformin use and risk of total joint replacement in patients with diabetes: a longitudinal cohort study of Alberta's Tomorrow Project.

ABSTRACT:

Purpose

To characterize the association between metformin use and risk of total joint replacement in patients with diabetes using data from Alberta's Tomorrow Project (ATP), a population-based cohort study of chronic diseases in Alberta, Canada.

Methods

The ATP participants with incidence of diabetes after enrollment were included and followed up to March 31, 2021. Metformin use, including daily doses, was measured by a time-varying approach during the follow-up. A multivariable Cox regression model was used to characterize the association between metformin use and risk of total joint replacement, after controlling for time-related variation in drug use, clinical status, BMI, lifestyles and concurrent medications.

Results

Among 3,001 incident cases of diabetes (52% fe

SUBMITTER: Ye M 

PROVIDER: S-EPMC11956490 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature