Integrated multi-omics landscape of non-small cell lung cancer with distant metastasis.

ABSTRACT:

Background

Distant metastasis is one of the important factors affecting the prognosis of lung cancer patients. Extracellular vesicles (EVs) play an important role in the occurrence, development, and metastasis of cancer. However, it is currently unclear whether EVs in BALF are involved in distant tumor metastasis.

Methods

we collected bronchoalveolar lavage fluid (BALF) from patients with metastatic and non-metastatic non-small cell lung cancer (NSCLC) to isolate exosomes, which were then characterized by nanoparticle tracking analysis (NTA) and transmission electron microscopy (TEM), followed by comprehensive metabolomic and proteomic analysis to ultimately construct a distant metastasis prediction model for non-small cell lung cancer.

Results

Our research has found

SUBMITTER: He T 

PROVIDER: S-EPMC11956740 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature