Topographic Analysis of Two-Wavelength Autofluorescence Supports Higher Macular Xanthophyll Pigment in AMD Than Aging: ALSTAR2 Baseline.

ABSTRACT:

Purpose

To advance metabolic imaging of the high-risk macula lutea by quantifying the topography of macular pigment optical density (MPOD), measured with two-wavelength autofluorescence (2WAF), and quantitative (short-wavelength) autofluorescence (qAF) intensity, which share the same signal source and cross-retinal light path, in aging, early (e), and intermediate (i) age-related macular degeneration (AMD).

Methods

2WAF and qAF images of 384 pseudophakic eyes of 230 persons (mean age, 74.2 ± 5.7 years; 145 female) from ALSTAR2 (AREDS 9-step classification: 170, normal; 118, eAMD; 96 iAMD) were shown as maps (intensity, z-score) and meridian plots. Correlations were determined in Early Treatment Diabetic Retinopathy Study (ETDRS) subfields.

Results

MPOD was higher in t

SUBMITTER: Goerdt L 

PROVIDER: S-EPMC11956744 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature