Real-World Effectiveness of BNT162b2 Against Infection and Severe Diseases in Children and Adolescents.

ABSTRACT:

Background

The efficacy of the BNT162b2 vaccine in pediatrics was assessed by randomized trials before the Omicron variant's emergence. The long-term durability of vaccine protection in this population during the Omicron period remains limited.

Objective

To assess the effectiveness of BNT162b2 in preventing infection and severe diseases with various strains of the SARS-CoV-2 virus in previously uninfected children and adolescents.

Design

Comparative effectiveness research accounting for underreported vaccination in 3 study cohorts: adolescents (12 to 20 years) during the Delta phase and children (5 to 11 years) and adolescents (12 to 20 years) during the Omicron phase.

Setting

A national collaboration of pediatric health systems (PEDSnet).

Participants

7

SUBMITTER: Wu Q 

PROVIDER: S-EPMC11956830 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature