PRC1 resists microtubule sliding in two distinct resistive modes due to variations in the separation between overlapping microtubules.

ABSTRACT: Crosslinked cytoskeletal filament networks provide cells with a mechanism to regulate cellular mechanics and force transmission. An example in the microtubule cytoskeleton is mitotic spindle elongation. The three-dimensional geometry of these networks, including the overlap length and lateral microtubule spacing, likely controls how forces can be regulated, but how these parameters evolve during filament sliding is unknown. Recent evidence suggests that the crosslinker PRC1 can resist microtubule sliding by two distinct modes: a braking mode and a less resistive coasting mode. To explore how molecular-scale mechanisms influence network geometry in this system, we developed a computational model of sliding microtubule pairs crosslinked by PRC1 that reproduces the experimentally observed bra

SUBMITTER: Steckhahn D 

PROVIDER: S-EPMC11956913 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature