Intrinsic OASL expression licenses interferon induction during influenza A virus infection.

ABSTRACT: Effective control of viral infection requires rapid induction of the innate immune response, especially the type I and type III interferon (IFN) systems. Despite the critical role of IFN induction in host defense, numerous studies have established that most cells fail to produce IFNs in response to viral stimuli. The specific factors that govern cellular heterogeneity in IFN induction potential during infection are not understood. To identify specific host factors that license some cells but not others to mount an IFN response to viral infection, we developed an approach for analyzing temporal scRNA-seq data of influenza A virus (IAV)-infected cells. This approach identified the expression of several interferon stimulated genes (ISGs) within pre-infection cells as correlates of IFN inducti

SUBMITTER: Rivera-Cardona J 

PROVIDER: S-EPMC11956916 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature