Methylglyoxal mutagenizes single-stranded DNA via Rev1-associated slippage and mispairing.

ABSTRACT: Methylglyoxal (MG) is a highly reactive aldehyde that is produced endogenously during metabolism and is derived from exogenous sources such as sugary food items and cigarette smoke. Unless detoxified by glyoxalases (Glo1 and Glo2), MG can readily react with all major biomolecules, including DNA and proteins, generating characteristic lesions and glycation-derived by- products. As a result, MG exposure has been linked to a variety of human diseases, including cancers. Prior studies show that MG can glycate DNA, preferentially on guanine residues, and cause DNA damage. However, the mutagenicity of MG is poorly understood in vivo. In the context of cancer, it is essential to comprehend the true contribution of MG to genome instability and global mutational burden. In the present study,

SUBMITTER: Vijayraghavan S 

PROVIDER: S-EPMC11956917 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature