Chemoselective Characterization of New Extracellular Matrix Deposition in Bioengineered Tumor Tissues.

ABSTRACT: The extracellular matrix (ECM), present in nearly all tissues, provides extensive support to resident cells through structural, biomechanical, and biochemical means, and in return the ECM undergoes constant remodeling from interacting cells to adapt to the evolving tissue states. Bioengineered 3D tissues, commonly known as cell-ECM composites, are robust model systems to recapitulate and investigate native pathophysiology. Key to this engineered morphogenesis process are the intricate cell-ECM interactions reflected by how cells respond to and thereby modulate their surrounding microenvironments through their ongoing ECM secretome. However, investigating ECM-regulated new ECM production has been challenging due to the proteomic background from the pre-existing biomaterial ECM. To address t

SUBMITTER: Ling Z 

PROVIDER: S-EPMC11956949 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature