Emulating Clinical Trials with the Mayo Clinic Platform: Cardiovascular Research Perspective.

ABSTRACT:

Background

Randomized controlled trials (RCTs) provide the highest level of clinical evidence but are often limited by cost, time, and ethical constraints. Emulating RCTs using real-world data (RWD) offers a complementary approach to evaluate the treatment effect in a real clinical setting. This study aims to replicate clinical trials based on Mayo Clinic Platform (MCP) electronic health records (EHRs) and emulation frameworks. In this study, we address two key questions: (1) whether clinical trials can be feasibly replicated using the MCP, and (2) whether trial emulation produces consistent conclusions based on real clinical data compared to the original randomized controlled trials RCTs.

Methods

We conducted a retrospective observational study with an adaption of trial emu

SUBMITTER: Li X 

PROVIDER: S-EPMC11957179 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature