Subthreshold moment analysis of neuronal populations driven by synchronous synaptic inputs.

ABSTRACT: Even when driven by the same stimulus, neuronal responses are well-known to exhibit a striking level of spiking variability. In-vivo electrophysiological recordings also reveal a surprisingly large degree of variability at the subthreshold level. In prior work, we considered biophysically relevant neuronal models to account for the observed magnitude of membrane voltage fluctuations. We found that accounting for these fluctuations requires weak but nonzero synchrony in the spiking activity, in amount that are consistent with experimentally measured spiking correlations. Here we investigate whether such synchrony can explain additional statistical features of the measured neural activity, including neuronal voltage covariability and voltage skewness. Addressing this question involves conduc

SUBMITTER: Becker LA 

PROVIDER: S-EPMC11957229 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature