Microsampling in toxicology studies - maximising the scientific, business and 3Rs advantages.

ABSTRACT: Adoption of a blood microsampling technique can reduce or avoid the use of satellite animals (rodents) for toxicokinetics or other purposes in discovery and toxicology studies and provides refinements applicable for both rodents and larger animals. Microsampling can increase the scientific value of data obtained from rodent studies during drug and (agro)chemical development, enabling multiple endpoints to be investigated and compared in an individual animal in the same way as non-rodents. A cross-sector survey was developed to understand the current use of microsampling in toxicology studies, with the aim of identifying the specific studies in which microsampling was employed and the barriers to wider uptake. A high proportion of the survey responses indicated that microsampling was used,

SUBMITTER: Prior H 

PROVIDER: S-EPMC11957253 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature