C5b-9 mediates ferroptosis of tubular epithelial cells in trichloroethylene-sensitization mice.

ABSTRACT: Occupational medicamentose-like dermatitis due to trichloroethylene (OMDT) is a key but unresolved question. OMDT patients often present multiple organ damage, including kidney damage. However, the underlying mechanism remains unknown. The purpose of our study was to explore the effect of tubule-specific C5b-9 deposition induced by TCE sensitization on renal tubular ferroptosis and its mechanism. By analyzing pathological changes of TCE-sensitization-mice kidney, we observed a significant renal tubular ferroptosis, which was alleviated by CD59, a C5b-9 inhibitory protein. Moreover, this phenomenon was also replicated in a C5b-9-attacked HK-2 cell model. Further experiments identified that C5b-9 induced cytosolic Ca²⁺ overload in renal tubular epithelia cells from TCE-sensitizati

SUBMITTER: Liu Z 

PROVIDER: S-EPMC11957332 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature