TphPMF: A microbiome data imputation method using hierarchical Bayesian Probabilistic Matrix Factorization.

ABSTRACT: In microbiome research, data sparsity represents a prevalent and formidable challenge. Sparse data not only compromises the accuracy of statistical analyses but also conceals critical biological relationships, thereby undermining the reliability of the conclusions. To tackle this issue, we introduce a machine learning approach for microbiome data imputation, termed TphPMF. This technique leverages Probabilistic Matrix Factorization, incorporating phylogenetic relationships among microorganisms to establish Bayesian prior distributions. These priors facilitate posterior predictions of potential non-biological zeros. We demonstrate that TphPMF outperforms existing microbiome data imputation methods in accurately recovering missing taxon abundances. Furthermore, TphPMF enhances the efficacy o

SUBMITTER: Han X 

PROVIDER: S-EPMC11957397 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature