VIPAS39 confers ferroptosis resistance in epithelial ovarian cancer through exporting ACSL4.

ABSTRACT:

Background

The high mortality rate associated with epithelial ovarian cancer (EOC) is primarily due to recurrence and chemoresistance, underscoring the urgent need for innovative therapeutic approaches that leverage newly identified vulnerabilities in cancer cells. While conventional chemotherapies induce apoptosis by targeting DNA or mitotic machinery, ferroptosis represents a new distinct form of programmed cell death characterised by the accumulation of lipid peroxides.

Methods

The sensitivity of different EOC cell lines to ferroptosis inducers was evaluated using cell viability assays and lipid peroxidation measurements. Live-cell imaging with the pH-sensitive CD63-pHuji reporter was performed to track the extracellular export of acyl-CoA synthetase long-chain family mem

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC11957506 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature