Health outcomes and their association with weight regain after substantial weight loss in Sweden: a prospective cohort study.

ABSTRACT:

Background

The clinical implications of weight regain following weight loss remain uncertain. We analysed mortality, cardiovascular events, cancer, and microvascular disease in individuals with significant weight loss, comparing maintainers to regainers.

Methods

Using a prospective cohort design, we analysed 1346 participants who underwent bariatric surgery in the Swedish Obese Subjects (SOS) study, aged 37-60 years with BMI ≥34 (men) or ≥38 (women), recruited 1987-2001. Individuals who regained ≥20% of their 1-year weight loss after 4 years (regain group) were compared to those who regained less (maintenance group). The study was closed on December 31, 2020 with median follow-up of 27 years and 99.9% mortality tracking (ClinicalTrials.govNCT01479452).

Findings

Averag

SUBMITTER: Carlsson LMS 

PROVIDER: S-EPMC11957514 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature