Dynamics of X chromosome hyper-expression and inactivation in male tissues during stick insect development.

ABSTRACT: Differentiated sex chromosomes are frequently associated with major transcriptional changes: the evolution of dosage compensation (DC) to equalize gene expression between the sexes and the establishment of meiotic sex chromosome inactivation (MSCI). Our study investigates the mechanisms and developmental dynamics of dosage compensation and meiotic sex chromosome inactivation in the stick insect species T. poppense. Stick insects are characterized by XX/X0 sex determination, with an X chromosome that likely evolved prior to the diversification of insects over 450 Mya. We generated a chromosome-level genome assembly and analyzed gene expression from various tissues (brain, gut, antennae, leg, and reproductive tract) across developmental stages in both sexes. Our results show that complete do

SUBMITTER: Djordjevic J 

PROVIDER: S-EPMC11957559 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature