Quantitative ultrasound and photoacoustic assessments of red blood cell aggregation in the human radial artery.

ABSTRACT: We develop concurrent US and photoacoustic (PA) imaging to characterize structural/physiological impact of in-vivo red blood cell (RBC) aggregation. PA images at 700/800/900 nm were collected from the radial arteries of 12 participants across age groups (20 s/30 s/40 s) alongside US images (21 MHz, VevoLAZR). RBC aggregate size was estimated from US-derived structure-factor-size-estimation (D _SFSE) and PA-derived spectral-slope (SS), along with oxygen saturation (sO₂). At peak systole (PS), D _SFSE ^PS and SS^PS approximated 1 RBC and -0.1 dB/MHz, respectively, across all ages, with sO₂ ^PS values of 97.1 %, 94.7 %, and 93.0 % for each group. At end diastole (ED), D _SFSE ^ED,

SUBMITTER: Bok T 

PROVIDER: S-EPMC11957594 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature