Insulitis and aging: Immune cell dynamics in Langerhans islets.

ABSTRACT: With increasing age, the risk for age-related type-2-diabetes also increases due to impaired glucose tolerance and insulin secretion. This disease process may be influenced by various factors, including immune cell triggered inflammation and fibrosis. Although immune cells are a necessary component of islets, little is known about immune cell accumulation, immune cell subtype shifts and subsequent influence on glucose metabolism in healthy aging. However, this is critical for understanding the mechanisms that influence β-cell health. Therefore, we studied young and old male C57BL/6J mice, focusing on immune cell composition, patterns of accumulation, and the presence of fibrosis within the pancreatic islets. Our findings demonstrate that insulitis occurs in healthy aged mice without immedi

SUBMITTER: Jelleschitz J 

PROVIDER: S-EPMC11957801 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature