Lipid abnormality in diabetic kidney disease and potential treatment advancements.

ABSTRACT: Numerous studies have shown that dyslipidemia increases the risk of atherosclerotic cardiovascular disease (ASCVD) and significantly impacts the occurrence and progression of diabetic kidney disease (DKD). Early interventions for lipid metabolism disorders in DKD may improve renal function. This article reviews the clinical characteristics of dyslipidemia, mechanisms of lipid-induced renal injury, and advances in lipid-lowering therapy in DKD. We searched PubMed, Web of Science, and EMBASE to identify relevant articles, using keywords such as "diabetic kidney disease", "diabetic nephropathy", "diabetes", "dyslipidemia", "kidney", "cardiovascular disease", and "lipid therapy". High triglyceride (TG) and low high-density lipoprotein (HDL) are associated with increased risks of albuminuria an

SUBMITTER: Tu QM 

PROVIDER: S-EPMC11958226 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature