Paired proteomic analysis reveals protein alterations in sun-exposed skin of professional drivers : ¹Laboratory for structural and Computational Proteomics, Carlos Chagas Institute, Fiocruz, Parana, Brazil.

ABSTRACT: Professional drivers represent an ideal cohort for investigating the effects of solar radiation on skin due to their unique, asymmetric exposure to sun, a consequence of vehicle window orientations. Consequently, one side of the face is naturally subjected to more solar radiation, resulting in uneven sunlight exposure. This scenario supports a paired experimental design for precise within-individual comparisons, crucial for assessing sun exposure's impact on skin health, including signs of aging. Leveraging this approach, our study reveals sun-induced overexpression of proteins linked to photoaging through paired proteomic analysis, providing novel insights into the skin's adaptive responses to chronic solar exposure. Initially, our research focused on a dataset from ten male professional

SUBMITTER: Camillo-Andrade AC 

PROVIDER: S-EPMC11958692 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature