Synthesis of novel sulphonamide derivatives from tunable quinolines with computational studies.

ABSTRACT: The synthesis of new quinoline-sulphonamide derivatives was accomplished through a meticulous five-step molecular assembly utilizing Suzuki, acid-amine cross-coupling reactions and N-alkylation. The integrity of each derivative was thoroughly confirmed via comprehensive spectroscopic analyses, including ¹H and ¹³C NMR, DEPT-135, ¹H-¹H COSY, HSQC NMR and HRMS techniques. Subsequently, the absorbance and emission spectra of the newly synthesized derivatives were thoroughly investigated. Absorbance spectra were determined to be restricted within the range of 337 nm to 341.73 nm, with compound 10j exhibiting the maximum wavelength of 341.73 nm; conversely, emission spectra were uniformly detected within the range of 411.70 nm to 429.90 nm upon excita

SUBMITTER: Chavan ND 

PROVIDER: S-EPMC11958747 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature