RmmLII, a novel marine-derived <i>N-</i>acyl homoserine lactonase from <i>Tritonibacter mobilis</i>.

ABSTRACT:

Introduction

Quorum sensing (QS) is a bacterial intercellular communication system that can regulate the expression of various virulence genes coordinate the group behaviors of the bacteria by sensing the concentration of signaling molecules in the surrounding environment. An increase in bacterial drug-resistance has been caused by the widespread use of antibiotics, making it urgent to identify safe and effective alternatives to antibiotics. Quorum quenching (QQ) is a strategy to control bacterial infections by disrupting the QS system, which reduces pathogenicity or increases biofilm susceptibility to antibiotics. Several natural agents with QQ activity have been identified, including small molecular inhibitors and QQ enzymes that disrupt bacterial QS by degrading or modifying the

SUBMITTER: Shen Y 

PROVIDER: S-EPMC11958948 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature