Environmental exposure to perchlorate, nitrate, and thiocyanate in relation to biological aging in U.S. adults, a cross-sectional NHANES study.

ABSTRACT:

Background

Few studies have investigated the associations between perchlorate, nitrate, and thiocyanate (PNT) and biological aging. This study aimed to assess the association between PNT and biological aging among U.S. adults.

Methods

Utilizing multivariable linear regression and restricted cubic splines (RCS), we analyzed urinary PNT levels' impact on phenotypic age and biological age. Subgroup and sensitivity analyses were also conducted. Weighted Quantile Sum (WQS) and Bayesian Kernel Machine Regression (BKMR) models examined PNT mixtures.

Results

8,368 participants were analyzed. Mean phenotypic age was 43.05 ± 0.48 years, mean biological age was 47.08 ± 0.4 years. Multivariable linear regression showed significant negative associations between higher PNT levels a

SUBMITTER: Kong W 

PROVIDER: S-EPMC11958956 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature