Hyperactivity in male and female mice manifests differently following early, acute prenatal alcohol exposure and mild juvenile stress.

ABSTRACT:

Introduction

Chronic prenatal alcohol exposure (PAE) and severe juvenile stress independently contribute to hyperactive and depressive behavioral phenotypes, with their combination exacerbating these effects. However, while chronic PAE and traumatic juvenile stress are well-studied, little is known about the impact of early, acute PAE and mild juvenile stress on hyperactivity and depression. This knowledge gap is clinically relevant, as these milder early-life insults are common in Western societies. Here, we provide the first investigation into the effects of early, acute PAE and juvenile sub-chronic, unpredictable, mild stress (SUMS)-both independently and in combination-on hyperactivity and depressive-like behaviors in mice throughout the lifespan.

Methods

We assessed hyp

SUBMITTER: Pietrantonio AF 

PROVIDER: S-EPMC11958967 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature