Characterizing HLA-A2-restricted CD8⁺ T-cell epitopes and immune responses to Omicron variants in SARS-CoV-2-inactivated vaccine recipients.

ABSTRACT:

Introduction

Recent surveillance has identified the emergence of the SARS-CoV-2 Omicron ariant, which exhibits the ability to evade multiple neutralizing antibodies generated by prior infection or vaccination. However, significant knowledge gaps remain regarding the CD8 T-cell immune reactivity to the Omicron variant. This study aims to evaluate the characteristics of HLA-A2-restricted CD8 T-cell epitopes from the Omicron variant and analyze epitope-specific CD8 T-cell responses to SARS-CoV-2 inactivated vaccines.

Methods

We conducted a comprehensive analysis of CD8 T-cell responses to SARS-CoV-2 inactivated vaccines, focusing on HLA-A2-restricted epitopes derived from the Omicron variant. Mutant epitopes were evaluated for their impact on antigen presentation and CD8 T-cell

SUBMITTER: Xiao C 

PROVIDER: S-EPMC11958996 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature