Pseudouridine synthase 1 promotes progression of hepatocellular carcinoma via <i>mTOR</i> and <i>MYC</i> signaling pathways.

ABSTRACT: Pseudouridine synthases (PUSs) are associated with the development and progression of various cancers. However, the role of pseudouridine synthase 1 (PUS1) on HCC is unclear. The purpose of this study is to explore the biological role and mechanism of PUS1 in HCC growth and progression. We identified the expression of PUS1 in HCC. The biological roles and downstream cell signaling pathways of PUS1 were explored to clarify the molecular mechanism of PUS1 in the growth and development of HCC. The results showed that the expression of PUS1 was correlated with HCC progression, metastasis, and poor survival. In addition, the knockdown of PUS1 dramatically inhibited cell proliferation and colony formation and promoted cell apoptosis. GSEA analysis revealed that c-MYC, DNA repair, and mTORC1 path

SUBMITTER: Chen L 

PROVIDER: S-EPMC11959026 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature