Impact of GABA and nutritional supplements on neurochemical biomarkers in autism: a PPA rodent model study.

ABSTRACT:

Background/objectives

Autism spectrum disorder (ASD) is associated with excitatory-inhibitory imbalance and oxidative stress. GABA, an inhibitory neurotransmitter, and related nutritional therapies are promising in restoring these imbalances. GABAergic deficits and glutamate excitotoxicity are two essential signaling pathways that could be addressed to treat autism, thus medications targeting these pathways are critical for treating behavioral symptoms. In a rat model of autism produced by propionic acid (PPA), this study assessed the effects of GABA supplementation and combined nutritional therapy (probiotics, vitamin D3) and β-lactam as an activator of glutamate transporter.

Methods

Sixty rats were randomly assigned into six groups: Group I (Control), Group II (PPA-

SUBMITTER: Alabdali AN 

PROVIDER: S-EPMC11959029 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature