A correlation study of serum tumor markers with systemic lupus erythematosus-associated interstitial lung disease.

ABSTRACT:

Background

Systemic lupus erythematosus-associated interstitial lung disease (SLE-ILD) is a pulmonary manifestation of SLE. Currently, serum biomarkers for early identification of SLE-ILD are lacking. Our study aimed to investigate the correlation and clinical significance of serum tumor markers (TMs) in patients with SLE-ILD.

Methods

We conducted a retrospective analysis of medical records from SLE patients between January 2017 and November 2023. We compared the differences in serum levels of TMs including carcinoembryonic antigen (CEA), carbohydrate antigens (CA125, CA15-3, and CA19-9), squamous cell carcinoma antigen (SCC), cytokeratin-19-fragment (CYFRA21-1), neuron-specific enolase (NSE) and ferritin (FER), between SLE-ILD and SLE patients.

Results

A total of 386

SUBMITTER: He X 

PROVIDER: S-EPMC11959046 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature