Rapid <i>in situ</i> formation of a double cross-linked network hydrogels for wound healing promotion.

ABSTRACT: The persistent challenge lies in accelerating wound healing. Bioactive hydrogels with in situ formation properties ensure that the dressing completely adheres to the wound and isolates it from external bacteria and microorganisms in order to meet the needs of damaged skin tissue for rapid hemostasis and wound healing. In this paper, hydrogel dressing that Polyacrylamide/Sodium alginate grafted with dopamine/Gelatin grafted with glycidyl methacrylate doped with Angelica sinensis polysaccharide was prepared (PDGA). Chemical cross-linking of PAAM by adding cross-linking agent to initiate free radical polymerization and photocross-linking by free radical polymerization of GMA-GEL under UV light irradiation are two cross-linking modes to construct dual-cross-linking network of PDGA hydro

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11959063 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature