Association between hyperlipidemia and postoperative delirium risk: a systematic review and meta-analysis.

ABSTRACT:

Introduction

The association between hyperlipidemia and its potential role as a risk factor for postoperative delirium (POD) remains unclear.

Methods

We systematically searched PubMed, Embase, Web of Science, Cochrane Library, and ClinicalTrials.gov to identify studies meeting the inclusion criteria. Outcomes of interest included comparisons of blood lipid levels between POD and non-POD (NPOD) patients, the association between hyperlipidemia and POD risk, and the predictive value of hyperlipidemia for POD.

Results

A total of nine studies involving 4,686 patients were included in the meta-analysis. Pooled analysis revealed that hyperlipidemia was significantly associated with an increased risk of POD (OR = 1.47; 95% CI 1.13-1.91; P = 0.004;) compared to patients

SUBMITTER: Qiu LQ 

PROVIDER: S-EPMC11959067 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature