A myeloid IFN gamma response gene signature correlates with cancer prognosis.

ABSTRACT:

Background

The IFN-γ cytokine plays a dual role in anti-tumor immunity, enhancing immune defense against cancer cells while promoting tumor survival and progression. Its influence on prognosis and therapeutic responses across cancer types remains unclear.

Objective

This study aimed to perform a pan-cancer analysis of IFN-γ response genes to determine their prognostic significance and evaluate their impact on clinical outcomes and anti-PD1 immunotherapy responses.

Methods

Using multiple datasets, 46 IFN-γ response genes were identified as prognostic for disease-specific survival, and their expression was used to construct the IFN-γ Response Gene Network Signature (IFGRNS) score. The prognostic and therapeutic relevance of the IFGRNS score was assessed across cancer typ

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11959096 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature