Dynamic Alterations in DNA Methylation of CD4⁺ T Cells and Macrophages in a Murine Model of Tuberculous Pleural Infection Induced by BCG Vaccination.

ABSTRACT: Tuberculous pleural effusion (TPE) is a prevalent form of extrapulmonary tuberculosis, and immune abnormalities play a crucial role in promoting its development. However, the dynamic changes and regulatory characteristics of immune cells during TPE progression remain incompletely understood. This study analyzed DNA methylation and transcriptome data from macrophages and CD4⁺ T cells from pleural lavage fluid of BCG-induced tuberculous pleurisy mouse models at specific time points (Days 0, 1, 7, and 14). The results revealed substantial alterations in DNA methylation patterns associated with inflammatory factors and interferon genes. Notably, macrophages exhibited the most pronounced differences in DNA methylation profiles on Day 1, while CD4⁺ T cells demonstrated grad

SUBMITTER: Shao MM 

PROVIDER: S-EPMC11959155 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature