An endogenous cholinergic system controls electrical conduction in the heart.

ABSTRACT:

Background and aims

The cholinergic system is distributed in the nervous system, mediating electrical conduction through acetylcholine (ACh). This study aims to identify whether the heart possesses an intact endogenous cholinergic system and to explore its electrophysiological functions and relationship with arrhythmias in both humans and animals.

Methods

The components of the heart's endogenous cholinergic system were identified by a combination of multiple molecular cell biology techniques. The relationship of this system with cardiac electrical conduction and arrhythmias was analysed through electrophysiological techniques.

Results

An intact cholinergic system including ACh, ACh transmitter vesicles, ACh transporters, ACh metabolic enzymes, and ACh receptors was id

SUBMITTER: Xie D 

PROVIDER: S-EPMC11959186 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature