Unique effect of clozapine on adenosine A_2A-dopamine D₂ receptor heteromerization.

ABSTRACT: The striatal dopamine D₂ receptor (D₂R) is generally accepted to be involved in positive symptoms of schizophrenia and is a main target for clinically used antipsychotics. D₂R are highly expressed in the striatum, where they form heteromers with the adenosine A_2A receptor (A_2AR). Changes in the density of A_2AR-D₂R heteromers have been reported in postmortem tissue from patients with schizophrenia, but the degree to which A₂R are involved in schizophrenia and the effect of antipsychotic drugs is unknown. Here, we examine the effect of exposure to three prototypical antipsychotic drugs on A_2AR-D₂R heteromerization in mammalian cells using a NanoBiT assay. After 16 h of exposure, a si

SUBMITTER: Valle-Leon M 

PROVIDER: S-EPMC11959194 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature