Improving Guideline Development Processes: Integrating Evidence Estimation and Decision-Analytical Frameworks.

ABSTRACT:

Rationale, aims and objectives

Despite using state-of-the-art methodologies like Grades of Recommendation, Assessment, Development and Evaluation (GRADE), current guideline development frameworks still rely heavily on panellists' intuitive integration of evidence related to the benefits and harms/burdens of health interventions. This leads to the 'black-box' and 'integration' problems, highlighting the lack of transparency in guideline decision-making. Combined with humans' limited capacity to process the large volumes of information presented in Summary of Findings (SoF) tables-the primary output of systematic reviews that underpin guideline recommendations-this reliance on non-explicit processes raises concerns about the trustworthiness of clinical practice guidelines.

Methods

SUBMITTER: Djulbegovic B 

PROVIDER: S-EPMC11959216 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature