Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons.

ABSTRACT:

Purpose

The detection of ctDNA, which allows noninvasive tumor molecular profiling and disease follow-up, promises optimal and individualized management of patients with cancer. However, detecting small fractions of tumor DNA released when the tumor burden is reduced remains a challenge.

Experimental design

We implemented a new, highly sensitive strategy to detect bp resolution methylation patterns from plasma DNA and assessed the potential of hypomethylation of long interspersed nuclear element-1 retrotransposons as a noninvasive multicancer detection biomarker. The Detection of Long Interspersed Nuclear Element Altered Methylation ON plasma DNA method targets 30 to 40,000 young long interspersed nuclear element-1 retrotransposons scattered throughout the genome, covering a

SUBMITTER: Michel M 

PROVIDER: S-EPMC11959274 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature