Symmetrical di-substituted phenylamino-<i>s</i>-triazine derivatives as anticancer agents: <i>in vitro</i> and <i>in silico</i> approach.

ABSTRACT: A series of symmetrical tri-substituted s-triazine derivatives were designed and synthesized by two different methods (reflux and microwave-assisted methods). The structures of compounds were determined by infrared (IR), nuclear magnetic resonance (¹H NMR and ¹³C NMR), and mass spectrometry. The yield of the microwave-assisted method (91-98%) was significantly higher (about 10%) than that of the reflux method (80-88%) meanwhile the reaction time was significantly shorter (15-30 min). Compound 3b showed good cytotoxic activity against the MCF7 (human breast cancer) cell line with an IC₅₀ value of 6.19 μM. Compounds 3a and 2e showed strong cytotoxic activity against the C26 (colon carcinoma) cell line with IC₅₀ values of 1.21 and 8.28 μM, re

SUBMITTER: Canh Pham E 

PROVIDER: S-EPMC11959361 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature