Generalized Pairwise Comparisons to Support Shared Decision-Making in the CODA Trial.

ABSTRACT:

Importance

Shared decision-making (SDM) can be made difficult by the multifaceted nature of outcome assessment. A rigorous method for analyzing results from multiple outcomes is called generalized pairwise comparisons (GPC), which could assist in SDM.

Objective

To examine whether GPC can be useful in SDM by using individual-patient data from the Comparison of Outcomes of Antibiotic Drugs and Appendectomy (CODA) trial.

Design, setting, and participants

This comparative effectiveness study used data from participants in the multicenter US CODA trial (conducted between May 2016 and March 2020). All possible pairs of patients (one from each arm) were formed to analyze each of 7 outcomes of interest sequentially. Data were analyzed between February 2020 and early 2024.

SUBMITTER: Salvaggio S 

PROVIDER: S-EPMC11959446 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature