Detection and population genetic analysis of kdr L1014F variant in eastern Ethiopian Anopheles stephensi.

ABSTRACT: Anopheles stephensi is a malaria vector that has been recently introduced into East Africa, where it threatens to increase malaria disease burden. The use of insecticides, especially pyrethroids, is still one of the primary malaria vector control strategies worldwide. The knockdown resistance (kdr) mutation in the IIS6 transmembrane segment of the voltage-gated sodium channel (vgsc) is one of the main molecular mechanisms of pyrethroid resistance in Anopheles. Extensive pyrethroid resistance in An. stephensi has been previously reported in Ethiopia. Thus, it is important to determine whether or not the kdr mutation is present in An. stephensi populations in Ethiopia to inform vector control strategies. In the present study, the kdr locus was analyzed in An. stephensi collected from ten urb

SUBMITTER: Samake JN 

PROVIDER: S-EPMC11959535 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature